Certified Emergency Nurse (CEN) Practice Test 2025 - Free CEN Practice Questions and Study Guide

Muscle cramping is associated with both hypercalcemia and hyperphosphatemia due to the role calcium and phosphate play in muscle function and neuromuscular excitability. In hypercalcemia, elevated calcium levels can affect the neuromuscular junction and lead to altered muscle contractions, which may manifest as muscle cramping. Similarly, hyperphosphatemia can lead to neuromuscular issues as phosphate plays a critical role in energy metabolism within muscle cells. When both conditions are present, the risk of muscle dysregulation increases, resulting in symptoms like cramping.

Other symptoms mentioned in the choices may relate to one of the conditions independently but are not specific indicators for both hypercalcemia and hyperphosphatemia. For example, severe fatigue might occur due to various metabolic disturbances but does not link directly to both electrolyte imbalances. Shortened ST segments are often associated with hypercalcemia alone and are not a symptom of hyperphosphatemia. Hypotension can occur due to various reasons, including dehydration or blood loss, but is not specifically tied to either hypercalcemia or hyperphosphatemia. Thus, muscle cramping stands out as a clear symptom that connects both electrolyte disturbances.